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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are typically described as a focus on the practical aspects of study design which include the recruitment process and consent, adhering and the use routinely available equipment.

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A pragmatic trial that uses different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is essential for a pragmatic trial to be reliable and reduce bias in results is also essential. However excessive heterogeneity could result in problems with the design of the trial.

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The goal of pragmatic trials is to mimic real-life situations and achieve the highest level of validity externally. They are usually ordered by policymakers and practitioners to guide their decisions. They can also be used to assess the causal relationship between an intervention and its results. However, they should not be used to substitute for explanation studies.

The pragmatism idea is controversial and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the clinical or physiological hypothesis, and 프라그마틱 데모 pragmatic trials that inform policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic study which includes the recruitment, design, and delivery of the intervention and follow-up.

The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) produced 34 articles, shown in red in Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the subject of pragmatic thinking. It is important to remember that the majority of these studies were conducted in primary care settings.