Because of its effects on serotonin and norepinephrine, Zoloft is more effective than other antidepressants for some patients. Zoloft works for how can i get generic zofran without insurance the majority of patients with major depression, panic disorder and obsessive compulsive disorder (OCD). It may also be prescribed off-label for bulimia nervosa, post-traumatic stress disorder, premenstrual dysphoric disorder, and social anxiety disorder.