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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often described as focusing on practical aspects of study design, including recruitment and consent, adherence and the use routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used different investigators and included participants from different geographical regions. This type of heterogeneity is essential for practical trials to be valid and 프라그마틱 also helps reduce bias in the results. However, too much heterogeneity can result in problems with the trial design.

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The purpose of pragmatic trials is to replicate real-life scenarios and to achieve maximum credibility externally. Usually, they are requested by practitioners and policymakers to guide their decisions. They also provide a useful method of determining the causality between the intervention and its effects. They should, however, not be used to replace the need for explanation studies.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials should replace tests for explanations or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm a physiological or clinical hypothesis as well as pragmatic trials, which inform the policy and practice of. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic study, including recruitment, design, 프라그마틱 홈페이지 delivery of the intervention and follow-up.

There is a positive increase in the number of pragmatic trials that are published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This is a sign that the health science community is becoming more acquaint to the subject of pragmatic thinking. It is important to keep in mind, however, that the majority of these studies were conducted in primary care settings.